About Rona Therapeutics

Rona Therapeutics is a pioneering RNA therapeutics platform company dedicated to discovery and development of modular and programmable RNA medicines to deliver to patients around the world. The company is founded by industry veteran with deep expertise in RNA therapeutics program execution and world leading scientific advisors with rigorous biology understanding in the RNA space.

INDUSTRY INFORMATION

Decoding RNA level therapies enables programmable and scalable modification without permanent DNA damage

Oligonucleotide Based Therapies

As a rapidly growing class of drug modalities, oligonucleotides are small (15–30 bp) nucleotide-based therapeutics which are capable of targeting DNA and RNA as well as other biomolecules. Oligonucleotides allow for precise and programmable targeting as they can theoretically be designed to selectively target any gene at RNA level.

RNA Editing

RNA editing is a molecular process through which some cells can make discrete changes to specific nucleotide sequences within an RNA molecule after it has been generated by RNA polymerase. The technology offers tunable nucleotide change, limited off-site targeting and potential for undruggable targets.

mRNA Therapeutics

mRNA is a long, polymeric molecule, composed of four different building blocks called nucleotides that translate genetic information from DNA to express proteins in cells to produce biological effects.

Razor™ Platform

We have built the Razor™ Platform as an innovation engine with three complementary drivers

Integrated Data Power
  • Computational platform to optimize sequence design, chemical modification and delivery system
  • Novel target identification from decoding phenotype to genotype via biomarker linkages
Proprietary Chemistry Platform
  • Homegrown, exquisitely novel chemical modification to enable differentiated nucleic acid therapeutics
  • Delivery platform established for liver and extrahepatic delivery across therapeutic area, i.e. CNS, ocular, oncology, etc
RNA & Target Biology Insights
  • Deep knowledge in RNA biological mechanism to deliver RNA medicines with improved efficacy and PK/PD profile
  • Biology insights to select promising and elusive targets of paramount fit for a diversified portfolio of RNA modalities

Rona Therapeutics offers the opportunity to create transformative medicine of RNA therapies and disrupt the trajectory of treating diseases across different therapeutic areas. The journey needs a talented group who are highly passionate, convicted, and creative to achieve scientific excellence. We are committed to make true innovation, help patients live healthier and longer and creating an environment that empowers great people to do great things.

Job Opportunities
Drug Delivery Group Leader
Key Responsibilities:

Drive and direct the discovery of novel delivery technology and platform to support RNA-based therapeutics, working in concert with partners in molecular and cellular biology, pharmacology, computational chemistry, ADME, structural biology, chemical development, and other key functions.

... more>>
Oligonucleotide CMC Lead
Key Responsibilities:

Lead drug substance / drug product development of oligonucleotides, analytical development, Quality Assurance and oversight of manufacturing process with external CDMO and future inhouse GMP manufacturing facility

... more>>

Rona Therapeutics offers the opportunity to create transformative medicine of RNA therapies and disrupt the trajectory of treating diseases across different therapeutic areas. The journey needs a talented group who are highly passionate, convicted, and creative to achieve scientific excellence. We are committed to make true innovation, help patients live healthier and longer and creating an environment that empowers great people to do great things.

Job Opportunities
Drug Delivery Group Leader
Key Responsibilities:

Drive and direct the discovery of novel delivery technology and platform to support RNA-based therapeutics, working in concert

... more>>
Oligonucleotide CMC Lead
Key Responsibilities:

Lead drug substance / drug product development of oligonucleotides, analytical development, Quality Assurance and oversight of manufacturing

... more>>